The immunofluorescence staining revealed significantly reduced amount of MCP in the endothelium of lesional SSc skin than in the healthy controls (median proportion of positive vessels—H: 0.35; lesional SSc: 0.12; non-lesional SSc: 0.25; ScGVHD: 0.22; p value of pairwise comparisons H vs lesional SSc = 0.0004; Bonferroni-adjusted level for significance = 0.0042) (Fig. 3). This evidence concerns the gene CD46 and systemic sclerosis.