We found that C5b-9 plasma concentrations were similar in the SSc patients and healthy controls (dcSSc 134 ng/ml, IQR 93–203; lcSSc141 ng/ml, IQR 89–202; H 124 ng/ml, IQR 82–159; p = 0.49); whereas, the serum levels of FH were higher in SSc patients with both diffuse and limited subsets (dcSSc patients 126 μg/ml, IQR 114–150, p = 0.0025; lcSSc patients 124 μg/ml, IQR 108–152; p = 0.0054), compared to healthy controls (108 μg/ml, IQR 93–120 μg/ml), according to the Bonferroni correction. This evidence concerns the gene FH and systemic sclerosis.