We found that PSCA rs2294008 CT/TT, PSCA rs2976392 AG/AA and PLCE1 rs2274223 AG/GG genotypes were associated with a significantly increased stomach cancer risk in a Chinese population, whereas, the MUC1 rs4072037 T>C were associated with decreased stomach cancer susceptibility. The gene discussed is PLCE1; the disease is gastric cancer.