In light of our previous finding [28] and that Hippo signaling and YAP itself plays a key role in the liver and liver cancer [8, 10, 13, 15, 27, 39–42] this result was unexpected, however, none of these earlier studies directly examined YAP expression in LPCs nor compared its abundance before and after LPC transformation. The gene discussed is YAP1; the disease is liver cancer.