These data revealed that SFV-F3A propagated to titers between 1.5 and 2 orders of magnitude lower that wt SFV after both low and high MOI infection (Fig. 2D) indicating that blocking the nsP3/G3BP interaction by point mutation of the N-terminal phenylalanine residue in both FGDF motifs attenuates viral infection. The gene discussed is SH2D3C; the disease is infection.