TRPA1 and gout: Against this background, our present findings, in which inhibition or depletion of TRPA1 significantly reduced edema formation and accumulation of proinflammatory cytokines and inflammatory cells in response to MSU crystals in synovial joint resembling subcutaneous air-pouch and in subcutaneous soft-tissue are reasonable and together with the results described recently [17,18] support the role of TRPA1 as a mediator of inflammatory responses in acute gouty arthritis.