Overweight participants had lower baseline serum NT-proBNP concentrations (median [5th to 95th percentile]; 36 pg/mL [10 to 144] versus 45 pg/mL [12 to 148], P<0.001) despite higher SBP (mean ±SD; 124±10 mm Hg versus 119±10 mm Hg, P<0.001) and higher DBP (78±7 mm Hg versus 75±7 mm Hg, P<0.001) compared with normal weight participants, and in the fully adjusted model 4, the odds ratio for incident hypertension was 0.82 (95%CI 0.69–0.96, P = 0.016) in overweight participants, whereas the corresponding estimate was 0.97 (95% CI 0.78–1.19, P = 0.75) in participants with BMI <25 kg/m2. This evidence concerns the gene NPPB and hypertensive disorder.