So far, Mtb-induced phagosomal rupture has only been observed atlater stages of infection, i. e, 3–5 dpi, akinetic situation, which cannot explain the very early, ESX-1-dependent release oftype I IFNs or IL-1β, that requires recognition of mycobacterial components bythe host cytosolic sensors [44]. The gene discussed is ESX1; the disease is infection.