SLC11A1 and infection: As assessed forvarious MOI, the intracellular mycobacterial load inside parental, Nramp-1S- orNramp-1R-transfected Raw264.7 cells was comparable at 3 dpi, when the phagosomalrupture was monitored (Fig. 4D).Thus, the functional Nramp-1R seems to provide protection againstMtb-induced phagosomal rupture for the benefit of the host cell.The Nramp-1-mediated rescue of the host cells occurred at any MOI and independentlyof the host cell proliferation rate, which as we noticed, both influence the controlof the infection (S5Fig.).