In this respect, the significantly increased gene expression of NCF2, coding for the cytosolic activating component p67-Phox of the plasmamembrane NOX2 complex, could potentially contribute to intracellular ROS generation, in case that in melanoma cells NOX2 is located also into intracellular membranes, as demonstrated in different cell types [41]. This evidence concerns the gene NCF2 and melanoma.