A few papers from other Authors have pointed out a potential role of Calpain-3 in human melanoma tumorigenesis and progression, as indicated by the higher expression levels of CAPN3 in melanoma tissues compared to other tumor types [6], and by CAPN3 down-regulation in melanoma cells sensitive to interferon-γ [7] or undergoing drug-induced terminal differentiation [8]. Here, CAPN3 is linked to neoplasm.