Moreover, functional analysis demonstrated that cyclin-dependent kinase inhibitor 1A (CDKN1A) and phosphodiesterase 7B (PDE7B), which exhibit decreased DNA methylation and increased gene expression in type 2 diabetes, result in impaired insulin secretion and exocyst complex component 3-like 2 (EXOC3L2), which exhibits increased DNA methylation and decreased gene expression in type 2 diabetes, results in decreased exocytosis from pancreatic beta cells [12]. Here, PDE7B is linked to type 2 diabetes mellitus.