We observed that the IFN-γRα expression started decreasing 3 hours after the infection (Fig. 1A) and Ara-LAM prevented the reduction in IFN-γRα expression in L. donovani-infected macrophages (Fig. 1A, 1B, 1C; p< 0.05) possibly by enhancing NF-κB binding to IFN-γRα promoter (Fig. 1D). This evidence concerns the gene NFKB1 and infection.