P2RY2 and chronic obstructive pulmonary disease: In vivo studies focusing on the P2Y2R have shown that activation of this receptor transiently increases microvascular leakage to macromolecules [5] and promotes extravasation of leukocytes in inflammatory conditions involving both micro- and macrovessels, including atherosclerosis, asthmatic airway inflammation, Alzheimer’s disease, autoimmune diseases, bacterial infection and chronic obstructive pulmonary disease (COPD) [6]–[11].