FA2H and hereditary spastic paraplegia: There is also an overlap with other genetic diseases, once thought as being distinct conditions and usually not associated with Iron accumulation, as an example, mutations in FA2H gene lead to a FAHN phenotype (of NBIA group) while mutation in the same gene causes a form of hereditary spastic paraplegia (HSP) (6) and a leukodystrophy with spastic paraparesis and dystonia (7).