APOH and systemic lupus erythematosus: During the last decade, the beneficial effects of IVIG in diverse conditions were improved by using target-specific IVIG (sIVIG) in vitro and in vivo in animal models on such conditions as lupus (anti-DNA-idiotype-sIVIG in lupus mice) or antiphospholipid syndrome (anti-β2GPI-idiotype-sIVIG in APS mice) as a novel approach to treat different immune-mediated conditions in a more accurate antigen-specific manner (22).