Tackenberg et al. found impaired inhibitory FcγRIIb expression on B-cells in CIDP with upregulation on monocytes and B-cells after clinically effective IVIG therapy, suggesting that strategies specifically targeting FcγRIIb might have therapeutic merit in this immune-mediated peripheral neuropathy (17). Here, FCGR2B is linked to chronic inflammatory demyelinating polyradiculoneuropathy.