Cancers have developed strategies to utilize the angiogenic role of VEGF to grow and metastasize, but this rapid and uncontrolled angiogenesis results in the blood vessels within tumors often having abnormal characteristics including tortuosity, random branching and variable lumen size (Gimbrone et al., 1972; Langenkamp and Molema, 2009). This evidence concerns the gene VEGFA and cancer.