73% and 52% of PDACs were immuno-positive for HNF1A (29/40) and MIA2 (32/61, Fig. 1b), respectively, which is in contrast to the MIA2 function as a major tumor suppressor in HCC13; this, however, is consistent with the phenotype of Hnf1a-deficient mice where growth and oncogenesis of pancreatic β cells were impaired and proliferation of hepatocytes was increased33. Here, MIA2 is linked to neoplasm.