Since MIA2 is functionally related to protein secretion and because the UPR, activated by ER stress, couples the secretory network to cell survival in the adult pancreas26, 27, 28, 29, 30, we hypothesized that the MIA2I141M variant may influence the UPR “homeostasis” in pancreatic cancer cells. Here, MIA2 is linked to familial pancreatic carcinoma.