More importantly, USP28 controls MYC stability through antagonizing the activity of the SCFFBW7 ubiquitin liagse complex, and that the stabilization of MYC by USP28 is required for proliferation of several tumour cells types and for inhibition of cell differentiation in colon carcinoma, however, the role of USP28 in lung cancer has not yet been determined 16. This evidence concerns the gene USP28 and neoplasm.