There were also grade 3 triglyceride increase, uterine polyp and cervical polyp (2 patients each), organizing pneumonia and interstitial lung disease (1 patient each), and grade 4 breast cancer (1 patient) in the 2-year group, and grade 3 gamma-glutamyltransferase increase (4 patients), uterine polyp and cervical polyp (2 patients each), alanine aminotransferase increase, white blood cell count decrease, hypertension, and varicose veins (1 patient each) in the 3-or-more-year group. The gene discussed is GPT; the disease is hypertensive disorder.