Most treatment-related AEs were of grade 1 and 2, but grade 3 uterine polyp (2 patients), cervical polyp (1 patient), and grade 4 breast cancer (1 patient) were observed in the 2-year group, and grade 3 alanine aminotransferase increase and hypertension (1 patient each) were reported in the 3-or-more-year group. The gene discussed is GPT; the disease is uterine polyp.