NR0B2 and oculocutaneous albinism type 1: Examination of renal pathology in mice subjected to folic acid-induced ATN revealed that, compared with SHP+/+ mice, SHP−/− mice showed an increased incidence of pathological hallmarks, including evidence of tubular necrosis, flattening of the tubular epithelium, tubular dilatation, tubular cast formation and loss of tubular cell nuclei (Fig. 4e).