Another study genotyped 2065 subjects (1085 with incident coronary heart disease and 980 non‐cases) selected from the Atherosclerosis Risk in Communities (ARIC) study, and reported Lys55Arg was associated with higher sEH activity in vivo, and greater risk of incident coronary heart disease in Caucasians 144. Here, EPHX2 is linked to coronary artery disorder.