Interestingly, dual inhibition of cyclo‐oxygenase 2 and soluble epoxide hydrolase may have synergistic anti‐angiogenic and anti‐cancer activity 177 Thus, progression of dual action agents may be a more enlightening route to unravel and balance the controversy between up‐regulating EETs and their effects on cancer activity. The gene discussed is PTGS2; the disease is cancer.