The Notch-Hes1 pathway promotes the proliferation of intestinal stem/progenitor cells and inhibits secretory cell development.14, 15, 16 Hes1 functions as a downstream target of both the Notch and Wnt signaling pathway in LS174T colon cancer cells,17 suggesting that crosstalk between Notch and Wnt signaling may take place via Hes1. This evidence concerns the gene HES1 and malignant colon neoplasm.