Similarly, TSC2 has been shown to inhibit Notch through the inhibition of mTORC1 signaling in MEF cells and in some cancer cell lines.30 In addition, TSC2 has been shown to inhibit Notch in an mTOR-independent fashion.31 Conversely, Notch signaling increases mTOR signaling in certain cell types. This evidence concerns the gene MTOR and cancer.