PIK3R1 and esophageal squamous cell carcinoma: However, significant ESCC risk associated with three mTOR SNPs, but not PIK3R1 SNPs, was each individually observed among subjects with BMI < 25.0 under the dominant genetic model (WV/VV vs. WW) (rs2295080: adjusted OR = 1.36, 95% CI = 1.07–1.73; rs1057079: OR = 1.31, 95% CI = 1.03–1.67, rs1014261: OR = 1.39, 95% CI = 1.01–1.92) (Tables 3,4,5).