APG acts as an inhibitor of adenine nucleotide translocator (ANT)-2, an ADP/ATP translocator which up-regulates death receptors (DR)-5 at the post-transcriptional level and sensitizes malignant PCa tumor cells to apoptosis-inducing ligands (Apo2L)/TNF-related apoptosis-inducing ligands (TRAIL), whereas ANT-2 silencing leads to the enhancement of Apo2L/TRAIL mediated apoptosis [135]. The gene discussed is TNFSF10; the disease is posterior cortical atrophy.