Faghihi et al. identified a conserved lncRNA, BACE1-AS, transcribed from the opposite strand of the BACE1 locus (11q 23.3), with 104 nucleotides of full complementarity to exon 6 of the human BACE1 mRNA, which regulates protein expression of the sense gene in the brain of an AD mouse model [83]. This evidence concerns the gene BACE1 and Alzheimer disease.