Similar to our in vitro results showed that the high affinity of GCR for integrin αvβ3-positive tumor cells, systemically administered GCR protein produced a considerably stronger bioluminescent signal in integrin αvβ3-positive U87MG tumors than in integrin αvβ3-negative CHO tumors (Figure 5(a)). This evidence concerns the gene NR3C1 and neoplasm.