A significant increase in serum biomarkers such as serum SGOT, SGPT, GGT, ALP, total bilirubin, and LDH was observed in animals treated with CCl4, which is indicative of hepatic failure. PCEE at a dose of 250 and 500 mg/kg p.o. pretreatment for 7 days decreased the levels of abovementioned parameters significantly (P < 0.05, P < 0.01, and P < 0.001) in groups III and IV. The gene discussed is GPT; the disease is liver failure.