They further found that ER stress underlies the development of steatosis in their Sirt7 deficient mice, as the Sirt7 deficient livers have increased ER stress that could be partially rescued by a small molecule chaperone, and viral mediated transgenic expression of Sirt7. Sirt7 over-expression could also reverse steatosis induced by a high-fat diet (HFD). This evidence concerns the gene SIRT7 and steatosis.