The recurrent translocations t(2;5)(p23;q35)/NPM1-ALK and t(2;5)(p23;q35)/SQSSTM1-ALK, and inversion inv(2)(p23q35)/ATIC-ALK involving the ALK gene are well known rearrangements on chromosome 2 in various lymphoma types. The gene discussed is NPM1; the disease is lymphoma.