INS and polycystic ovary syndrome: Romualdi et al in a study on 12 obese, hyperinsulinemic, and dyslipidemia women with PCOS showed phytoestrogens supplementation improved total cholesterol, low-density lipoprotein and LDL/HDL ratio whereas had no effect on anthropometric features, the hormonal status, glucose and insulin metabolism and menstrual cycles (49).