In this review, the study of Salehpour et al through a prospective double-blind clinical trial on 46 PCOS women showed 6 weeks use of NAC can increase ovulation rate and HDL levels and decrease weight, body mass index (BMI), and waist/hip ratio, fast blood sugar (FBS), serum insulin, total cholesterol, LDL levels, and HOMA-IR index while luteinizing hormone (LH), Follicle-stimulating hormone (FSH), prolactin, LH/FSH levels and glucose/insulin ratio were the same with no significant changes (27). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.