FCGR3A and cytomegalovirus infection: However, even in the absence of TCR stimulation, CD16+ Vδ2neg γδ T cells produce interferon-γ and inhibit CMV replication when activated by IgG-opsonized free CMV, in presence of IL-12 and interferon-α, two cytokines produced by monocytes/macrophages and dendritic cells during CMV infection (Figure 3B) (115).