NOS2 and hypertensive disorder: Interestingly, bilateral injection of an NMDA receptor antagonist, NOS inhibitor, or NO scavenger into the dorsal hippocampus attenuated autonomic responses such as hypertension and tachycardia following a 60 min acute restraint stress, suggesting that NMDA/NOS activation within the hippocampus plays a role in autonomic modulation during stress (Moraes-Neto et al., 2014).