Pharmacological manipulation of therapeutic targets such as leucine rich repeat and Ig domain containing 1 (Jepson et al., 2012), retinoic X receptors (Huang et al., 2011), phosphodiesterase-7 (Medina-Rodríguez et al., 2013) and cyclin-dependent kinase 5 (Cdk5) (Luo et al., 2014) or signaling pathways such as the Fyn-Rho-ROCK and protein kinase C (PKC) (Baer et al., 2009) and the Notch/Jagged1 (Blanchard et al., 2013), can be advantageous for the repair of MS lesions. The gene discussed is CDK5; the disease is myeloid sarcoma.