ERN1 and Insulin resistance: Importantly, we found that with the inhibition of mTORC1 by rapamycin was correlated with the decreased of inflammatory cytokines and signalling pathway NFκB. Rapamycin in macrophages protects mice against inflammation and insulin resistance potentially by inhibiting HFD- and palmitic acid-induced IRE1α/JNK/NFκB pathways activation [38].