TBL1X, for which we demonstrated increased protein dosage in the context of its aberrant reactivation from the Xi, belongs to a complex with HDAC3 that is directly linked to several forms of cancer (Spurling et al. 2008; López-Soto et al. 2009; Kim et al. 2010; Müller et al. 2013; Miao et al. 2014). The gene discussed is TBL1X; the disease is cancer.