INS and type 2 diabetes mellitus: Moreover, in cultured primary myocytes from normal subjects, obese patients, or patients with T2D, where BRS-3 is natively expressed, the insulin-mimetic effects of [D-Tyr6,β-Ala11,Phe13,Nle14] bombesin6–14 have been reported, which involve an increase in kinase phosphorylation [MAPKs, p90RSK1, protein kinase B (PKB) and p70s6K], thus improving glucose metabolism, with cells from obese patients and patients with T2D being more sensitive to the ligand than cells from normal subjects (18).