Our results revealed that in myocytes from patients with OB/T2D, treatment with [D-Tyr6,β-Ala11,Phe13,Nle14] bombesin6–14 at 10−11 M induced a significant increase in GSa activity similar to that exerted by higher concentrations of insulin (10−9 M), almost having a normalizing effect, as previousy observed in patients with in OB or T2D (18). Here, INS is linked to type 2 diabetes mellitus.