Moreover, in primary myocytes isolated from normal subjects and patients with altered metabolic states (patients with obesity or T2D, where BRS-3 is natively expressed), the insulin-mimetic effects of [D-Tyr6,β-Ala11,Phe13,Nle14] bombesin6–14 have been observed (18). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.