Although no effects of insulin on glucose uptake in adipocytes in BRS-3-KO mice (possibly due to an impaired GLUT-4 translocation) has been observed (11), in our study, in myocytes from patients with OB/T2D, both the BRS-3 agonist and insulin affected glucose transport, as has been previously reported in myocytes from patients with either OB or T2D (5,26,27). This evidence concerns the gene BRS3 and type 2 diabetes mellitus.