In vitro experiments carried out on myocytes from normal subjects and patients with obesity or T2D have demonstrated the ability of insulin to enhance BRS-3 expression (5), which may also be a possible mediator in the regulation of BRS-3 gene expression, as BRS-3 expression has been detected in cells expressing high levels of insulin receptor, such as fibroblasts, where certain regulatory processes are produced by the hormone (24,25). This evidence concerns the gene INSR and type 2 diabetes mellitus.