Increases in MAPK, p90RSK1, PKB and p70s6K phosphorylation were detected, with myocytes from patients with obesity and T2D being more sensitive to the ligand than those from normal subjects; cells from patients with T2D were even more sensitive than those from patients with obesity (18). The gene discussed is RPS6KB1; the disease is obesity due to melanocortin 4 receptor deficiency.