It has been speculated that increased body volume caused by excessive body fat could lead to a higher peripheral vascular resistance and a series of dysfunction, such as adiponectin deficiency, hyperleptinemia, elevated renin-angiotensin-aldosterone system hormones and mineralocorticoid-stimulating factors.30, 31, 32 These dysfunctions may in turn activate the renin-angiotensin-aldosterone system and sympathetic nervous system, which lead to endothelial dysfunction, impaired pressure natriuresis and vascular hypertrophy, and eventually raise blood pressure. The gene discussed is ADIPOQ; the disease is hyperinsulinemic hypoglycemia, familial, 4.