We also found that the frequency of IL-21+ cells among the Tcm subset was still significantly increased in type 1 diabetes patients (geometric mean 5.33% [95% CI 4.75, 5.98] and 4.21% [95% CI 3.81, 4.66], respectively, p = 2.8 × 10−3; ESM Fig. 4c). The gene discussed is IL21; the disease is type 1 diabetes mellitus.