Clearly, Mfn1 and 2 have distinct roles: a single Mfn1 allele and no Mfn2 expression in mice did not affect baseline cardiac function, whereas mice with a single cardiac Mfn2 allele and no Mfn1 expression developed cardiomyopathy at 8 weeks of age [17]. Here, MFN2 is linked to cardiomyopathy.