For example, the candidate gene with the highest number of somatic non-silent mutations in The Cancer Genome Atlas (TCGA) low-grade glioma database is G6PC with three tumor samples containing missense somatic variants, followed by one tumor sample for each of MYO19, GHDC  ̧ and KRT27. Looking at the combined low-grade glioma and glioblastoma multiforme TCGA data, G6PC remains the gene with the highest number of somatic non-silent mutations (four tumor samples) followed by MYO19 (three tumor samples) and KIF18B (two tumor samples). This evidence concerns the gene GHDC and central nervous system cancer.