Interestingly, the fluorescence levels of E-cadherin and CD11c in the lung tumour were low, with E-cadherin only expressed in a minor fraction of the lung tissue of C57BL/6 mice, whereas the expression of E-cadherin and CD11c in the lung tissue of Rag1 KO mice exposed to an anti-CD40 antibody was increased and significantly greater than their expression in the Lewis orthotopic lung cancer model and C57BL/6 mice (Figure 1A). This evidence concerns the gene RAG1 and lung cancer.