IBSP and neoplasm: The development of BMs is a multifactorial process that requires a series of interactions between invading tumor cells and the bone microenvironment [18-20] and is sustained by the release of factors, such as transforming growth factor-β (TGF-β), bone morphogenetic proteins (BMPs) and bone sialoprotein (BSP), due to tumor-induced activity of osteoclasts [11,21,22].