We selected five of these (ACACA, CETP, CTGF, S100A8, S100A9) for further analyses based on reported adipose or adipocyte gene expression changes in response to weight loss/dietary intervention (ACACA, CETP, CTGF [66-69]), and/or associations with obesity or related traits (GWAS, and/or other literature). This evidence concerns the gene S100A8 and obesity due to melanocortin 4 receptor deficiency.