Furthermore, Rönn et al. recently reported differential methylation of a number of obesity candidate loci in thigh subcutaneous adipose after exercise; we observed differential methylation at single CpG sites within four of these: NRXN3 (∆beta 0.03, Chr14: 79747774), STAB1 (∆beta 0.12, Chr3: 52553167), TUB (∆beta 0.11, Chr11: 8084670), ZNF608 (∆beta 0.15, Chr5: 124013536). The gene discussed is NRXN3; the disease is obesity due to melanocortin 4 receptor deficiency.