For omentum we selected the CpG probe sites in the four genes with known or potential roles in obesity MYO1C, PLIN4, PARD3 and PDE7B. Significant correlations between methylation measures was observed for PDE7B (R2 = 0.671, P = 1.9 × 10−8), PLIN4 (R2 = 0.399, P = 0.0001) and PARD3B (R2 = 0.528, P = 2.4 × 10−6). Here, PDE7B is linked to obesity due to melanocortin 4 receptor deficiency.