Six genes/loci were selected from the subcutaneous adipose analysis based on a number of criteria: (1) most hyper- and hypomethylated before and after weight loss (CMIP and IFFO1, see Table 3); (2) genes implicated in obesity and/or type-2 diabetes (KCNQ1, CETP, CMIP, ADRAB2); and/or (3) reported differential adipose mRNA expression in response to weight loss/dietary intervention (CETP, CTGF). This evidence concerns the gene KCNQ1 and obesity due to melanocortin 4 receptor deficiency.