INS and obesity due to melanocortin 4 receptor deficiency: MYO1C is an actin-based motor protein involved in GLUT4 translocation, and insulin-dependent actin filament remodelling [51-53,56,61]; a SNP variant in PARD3 has been associated with type-2 diabetes [50]; members of the PDE7B gene family (PDE3B in particular) play a central role in the regulation of lipolysis, lipogenesis and glucose uptake [54,62], and SNP variants in PLIN4 have been associated with obesity, insulin resistance and increased blood lipids [55,57-60].