PTPN6 and obesity due to melanocortin 4 receptor deficiency: When we investigated the list of 162 DMRs mapping to annotated loci (Additional file 3) in further detail we observed other genes with known and potential roles in obesity and related traits (such as PRKCZ, NDUFS2, GATA2, FOXP2, ANGPT2, NCOR2, CPT1B, PTPN6).