IRS1 and obesity due to melanocortin 4 receptor deficiency: We saw differential methylation within 9/57 obesity (single CpG sites within: LEPR, STAB1, ZNF608, HMGA1, MSRA, TUB, NRXN3, FTO, MC4R) and 10/59 type-2 diabetes (single CpG sites: PROX1, RBMS1, IRS1, TCF7L2, FTO, LMNB2, INSR. Two CpG sites within AKT2, BCL11A. Six CpG sites within KCNQ1) genes in subcutaneous adipose.