In prohibitin 1 (Phb1)-KO mice, neddylation inhibition correlates with a strong modulation of the cancer metabolic signature and liver tumor regression, as a consequence of tumor cell death and characterized by: a) reduced levels of total sphingomyelines (SM) and a variety of diacylglycerols (DAG), succinate, GTP, malonyl-CoA, glycine; and b) augmented glycolic acid, triacylglycerols (TAG) levels and the phosphatiylcholines (PC) synthesis phosphatidylethanolamine methyltransferase (PEMT) flux. This evidence concerns the gene PHB1 and cancer.