In order to assess the biological influence of IFIT3 expression on the malignant potential of pancreatic cancer cells, COLO357FG cells and L3.6pl cells were stably transfected with either vectors resulting in over-expression of IFIT3 (CMV-IFIT3) or empty vectors as control (CMV-null) (figure 1A, bottom). This evidence concerns the gene IFIT3 and familial pancreatic carcinoma.