Acute oral administrations of the whole plant extract also caused dose-related significant hypoglycaemia in normal (normoglycaemic) and STZ-treated diabetic rats [125]. M. charantia extract also improved insulin sensitivity, glucose tolerance, and insulin signalling in high fat diet-induced insulin resistance rats [126]. M. charantia also maintained the normal glucose concentration in chronic sucrose loaded rats [71]. Here, INS is linked to Insulin resistance.