Previous studies that analyzed DNMT3A mutations showed that the incidence of DNMT3A mutation is 18–22% of AML and 29–34% of NK AML [24–27], including the largest study which analyzed 489 AML patients and reported the frequency of DNMT3A mutation as 17.8% of AML patients and 27.2% of NK AML patients [24]. This evidence concerns the gene DNMT3A and acute myeloid leukemia.