In addition, although two recent studies reported poor prognostic impact of DNMT3A mutations in Chinese and Taiwanese AML patients [28, 29], studies which analyzed the clinical relevance of DNMT3A mutations in Asian population are outnumbered compared to Western population and there have been no reports on the clinical impact of DNMT3A mutations in Korean AML patients. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.