DNMT3A and acute myeloid leukemia: In addition, from our present study result it can be speculated that the adverse prognostic effect of DNMT3A mutations may not exist in overall Korean NK AML patients and although some variations are predicted to be deleterious to protein function in our study, the adverse prognostic impact may reside in all non-synonymous variations of DNMT3A gene and, therefore, all 23 exons of DNMT3A gene should be screened for the detection of clinically important DNMT3A mutations.