Our results are consistent with previous studies, which found that the intake of fructose rich diets markedly induce impairment in glucose tolerance leading to hyperglycemia and hyperinsulinemia.18 The major finding of the study was the treatment of SMC that significantly improves the high fructose induced oxidative stress as indicated by the decreased malondialdehyde and increased catalase, GPx and reduced glutathione activities and insulin resistance as indicated by decreased glucose, insulin and HOMA–IR. This evidence concerns the gene CAT and hyperinsulinism.