DDIT3 and McLeod neuroacanthocytosis syndrome: Cytogenetically, most cases of MLS show specific chromosomal translocation t(12;16)(q13;p11) resulting in the formation of a FUS-DDIT3 (also known as TLS-CHOP) fusion transcript [8–17], although occasional tumors exhibit the variant t(12;22) (q13;q12), producing an EWSR1-DDIT3 fusion transcript [1, 18].