On the other hand, perilipin showed a strong positive staining in large fat vacuoles of signet ring and multivacuolated lipoblasts as well as mature adipocytes in lipoma-like components of MLSLC and WDLS, but myxoid areas of MLSLC and DDLS contained a few cells possessing small fat vacuoles positive for perilipin. This evidence concerns the gene PLIN1 and lipoma.