A few of these adipokines are characterised by their favourable effects to maintain the body's energy and vascular homeostasis; however, adipokines have also been implicated in the pathogenesis of obesity-related disorders, such as atherosclerosis, specifically, by increasing the expression of proangiogenic/proatherogenic factors like endothelial gelatinases (matrix metalloproteinases 2 and 9) and vascular endothelial growth factor (VEGF) [6]. The gene discussed is VEGFA; the disease is atherosclerosis.