GHRL and Cachexia: The combination of these actions suggests that, this peptide has a beneficial effect on the prevention of cachexia and PEM.6-12 Ghrelin administration can improve appetite in adult patients on peritoneal dialysis.13,14 Recent studies showed that, the concentration of plasma ghrelin is inversely correlated with body mass index (BMI) and age in healthy children.6 Few number of anorexigenic peptide which compete against ghrelin on appetite regulation are leptin and obestatin.