VEGFA and cancer: Angiogenesis is critical for the growth and metastasis of invasive tumors and constitutes an important component in the suppression of cancer formation.1 The process of transporting excess nutrients, producing some risk factors, and forming tumor blood vessels and a route for tumor cell egress induces tumor aggression, growth, and dissemination.2,3 Vascular endothelial growth factor (VEGF) acts as an angiogenic inducer that is an endothelial cell-specific mitogen, and as a mediator of vascular permeability, playing a central role in the regulation of this process.