Enhanced VEGF expression and increased intratumoral microvessel density are related to an advanced stage disease and worse prognosis for a variety of women-specific malignancies, such as ovarian cancer5,6 and breast cancer.7,8 The highly polymorphic VEGF gene comprises eight exons that produce different proteins by alternative splicing of a unique transcript generated from a single-copy gene.9 There are more than 100 single nucleotide polymorphisms (SNPs) identified in the VEGF gene to date (http://www.ncbi.nlm.nih.gov/SNP). The gene discussed is VEGFA; the disease is breast carcinoma.