Data from experimental and clinical research have suggested that breast cancer is an angiogenesis-dependent disease closely associated with the serum level of VEGF.51 The potentially functional polymorphism in the VEGF gene, +936 C/T, was shown to correlate with lower VEGF production.13,15 It is the biological function of +936 C/T that leads to widespread attention towards the association between presence of +936 C/T polymorphism and breast cancer susceptibility. This evidence concerns the gene VEGFA and breast cancer.